Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease.

ABSTRACT: Prior studies of aging and Alzheimer disease have evaluated resting state functional connectivity (FC) using either seed-based correlation (SBC) or independent component analysis (ICA), with a focus on particular functional systems. SBC and ICA both are insensitive to differences in signal amplitude. At the same time, accumulating evidence indicates that the amplitude of spontaneous BOLD signal fluctuations is physiologically meaningful. We systematically compared covariance-based FC, which is sensitive to amplitude, vs. correlation-based FC, which is not, in affected individuals and controls drawn from two cohorts of participants including autosomal dominant Alzheimer disease (ADAD), late onset Alzheimer disease (LOAD), and age-matched controls. Functional connectivity was computed over 2

SUBMITTER: Strain JF 

PROVIDER: S-EPMC9750733 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature