SFRP4⁺IGFBP5^hi NKT cells induced neural-like cell differentiation to contribute to adenomyosis pain.

ABSTRACT:

Background

Adenomyosis is an estrogen-dependent gynecological disease. The pathogenesis of chronic pain, the main clinical symptom of adenomyosis, remains undefined. As a combination lymphocyte with both T-cell and natural killer (NK)-cell properties, NK T (NKT) cells play a role in immune defense against numerous diseases and modulate cell differentiation.

Method

This study analyzed the tissue-cell samples from adenomyosis with or without pain by single-cell sequencing.

Result

We found a specific population of secreted frizzled-related protein 4 (SFRP4)⁺NKT cells and a large amount of undifferentiated multipotent stem cells in the adenomyosis pain group. We discovered that a high expression of IGFBP5 in SFRP4⁺NKT cells could promote the d

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9750790 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature