A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.

ABSTRACT: Systematically identifying synergistic combinations of targeted agents and immunotherapies for cancer treatments remains difficult. In this study, we integrated high-throughput and high-content techniques-an implantable microdevice to administer multiple drugs into different sites in tumors at nanodoses and multiplexed imaging of tumor microenvironmental states-to investigate the tumor cell and immunological response signatures to different treatment regimens. Using a mouse model of breast cancer, we identified effective combinations from among numerous agents within days. In vivo studies in three immunocompetent mammary carcinoma models demonstrated that the predicted combinations synergistically increased therapeutic efficacy. We identified at least five promising treatment strategies, o

SUBMITTER: Tatarova Z 

PROVIDER: S-EPMC9750874 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature