Low number of neurosecretory vesicles in neuroblastoma impairs massive catecholamine release and prevents hypertension.

ABSTRACT:

Introduction

Neuroblastoma (NB) is a pediatric cancer of the developing sympathetic nervous system. It produces and releases metanephrines, which are used as biomarkers for diagnosis in plasma and urine. However, plasma catecholamine concentrations remain generally normal in children with NB. Thus, unlike pheochromocytoma and paraganglioma (PHEO/PGL), two other non-epithelial neuroendocrine tumors, hypertension is not part of the usual clinical picture of patients with NB. This suggests that the mode of production and secretion of catecholamines and metanephrines in NB is different from that in PHEO/PGL, but little is known about these discrepancies. Here we aim to provide a detailed comparison of the biosynthesis, metabolism and storage of catecholamines and metanephrines between

SUBMITTER: Muhlethaler-Mottet A 

PROVIDER: S-EPMC9751011 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature