Asgard ESCRT-III and VPS4 reveal conserved chromatin binding properties of the ESCRT machinery.

ABSTRACT: The archaeal Asgard superphylum currently stands as the most promising prokaryotic candidate, from which eukaryotic cells emerged. This unique superphylum encodes for eukaryotic signature proteins (ESP) that could shed light on the origin of eukaryotes, but the properties and function of these proteins is largely unresolved. Here, we set to understand the function of an Asgard archaeal protein family, namely the ESCRT machinery, that is conserved across all domains of life and executes basic cellular eukaryotic functions, including membrane constriction during cell division. We find that ESCRT proteins encoded in Loki archaea, express in mammalian and yeast cells, and that the Loki ESCRT-III protein, CHMP4-7, resides in the eukaryotic nucleus in both organisms. Moreover, Loki ESCRT-III pro

SUBMITTER: Nachmias D 

PROVIDER: S-EPMC9751279 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature