Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus.

ABSTRACT: Hindbrain NTS neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake but the relevant neural phenotypes and pathways remain elusive. Here, we investigated the role of NTS A2 neurons and their projections in the control of feeding behaviors. In male TH Cre rats, we first confirmed selective targeting of NTS A2 neurons and showed that chemogenetic stimulation of these neurons significantly suppressed dark cycle food intake, deprivation re-feed and high fat diet intake. Despite reducing intake, activation of NTS A2 neurons had no effect on food approach, anxiety-like behaviors, locomotor activity, blood glucose levels nor did it induce nausea/malaise, thus revealing a selective role for these neurons in the consumm

SUBMITTER: Murphy S 

PROVIDER: S-EPMC9751294 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature