Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction.

ABSTRACT: Extinction training during the reconsolidation window following memory recall is an effective behavioral pattern for promoting the extinction of pathological memory. However, promoted extinction by recall-extinction procedure has not been universally replicated in different studies. One potential reason for this may relate to whether initially acquired memory is successfully activated. Thus, the methods for inducing the memory into an active or plastic condition may contribute to promoting its extinction. The aim of this study is to find and demonstrate a manipulatable neural circuit that engages in the memory recall process and where its activation improves the extinction process through recall-extinction procedure. Here, naloxone-precipitated conditioned place aversion (CPA) in morphine-

SUBMITTER: Dai Z 

PROVIDER: S-EPMC9751301 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature