Association between loneliness and dementia risk: A systematic review and meta-analysis of cohort studies.

ABSTRACT: Loneliness has been reported to be associated with an increased risk of dementia; however, the extent of this relationship remains controversial. This study aimed to assess the strength of the relationship between loneliness and dementia using a meta-analysis approach. PubMed, EMBASE, and China National Knowledge Internet databases were systematically searched for potentially included studies from inception up to 17 February 2022. A meta-analysis was performed using a random-effects model to assess pooled relative risks (RRs) and 95% confidence intervals (CIs). A literature search identified 16 cohort studies (published in 15 articles), among which 4,625 dementia cases and 62,345 individuals were selected for further meta-analysis. Loneliness was associated with an increased risk of Alzhei

SUBMITTER: Qiao L 

PROVIDER: S-EPMC9751343 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature