Immune landscape-based machine-learning–assisted subclassification, prognosis, and immunotherapy prediction for glioblastoma

ABSTRACT:

Introduction

As a malignant brain tumor, glioblastoma (GBM) is characterized by intratumor heterogeneity, a worse prognosis, and highly invasive, lethal, and refractory natures. Immunotherapy has been becoming a promising strategy to treat diverse cancers. It has been known that there are highly heterogeneous immunosuppressive microenvironments among different GBM molecular subtypes that mainly include classical (CL), mesenchymal (MES), and proneural (PN), respectively. Therefore, an in-depth understanding of immune landscapes among them is essential for identifying novel immune markers of GBM.

Methods and results

In the present study, based on collecting the largest number of 109 immune signatures, we aim to achieve a precise diagnosis, prognosis, and immunotherapy predi

SUBMITTER:  

PROVIDER: S-EPMC9751405 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature