The crosstalk within the breast tumor microenvironment in type II diabetes: Implications for cancer disparities.

ABSTRACT: Obesity-driven (type 2) diabetes (T2D), the most common metabolic disorder, both increases the incidence of all molecular subtypes of breast cancer and decreases survival in postmenopausal women. Despite this clear link, T2D and the associated dysfunction of diverse tissues is often not considered during the standard of care practices in oncology and, moreover, is treated as exclusion criteria for many emerging clinical trials. These guidelines have caused the biological mechanisms that associate T2D and breast cancer to be understudied. Recently, it has been illustrated that the breast tumor microenvironment (TME) composition and architecture, specifically the surrounding cellular and extracellular structures, dictate tumor progression and are directly relevant for clinical outcomes. In a

SUBMITTER: Ennis CS 

PROVIDER: S-EPMC9751481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature