Clinicopathologic Significance of Predominant Lambda Light Chain Deposition in IgA Nephropathy.

ABSTRACT:

Introduction

IgA nephropathy (IgAN) differs from other glomerular diseases by the frequently predominant lambda over kappa light chain deposition. Using the Cure Glomerulonephropathy (CureGN) IgAN cohort, we aimed to determine whether predominant lambda chain deposition is associated with worse clinical outcomes or histopathologic markers of more active disease.

Methods

Patients were categorized based on the intensity of light chain staining. The lambda dominant (LD) group was defined by a difference in intensity score of lambda minus kappa ≥ 1+ and the kappa-lambda codominant (KL) group by a difference < 1+. We compared the clinical course of patients in each category from the time of kidney biopsy and time of enrollment into CureGN to the time of remission (proteinuria < 0

SUBMITTER: Ravipati P 

PROVIDER: S-EPMC9751582 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature