Mismatches in Gene Deletions and Kidney-related Proteins as Candidates for Histocompatibility Factors in Kidney Transplantation.

ABSTRACT:

Introduction

The genomic mismatch level between donor and recipient may be associated with the risk of rejection and graft survival. We determined the association of genome-level matching with acute rejection in deceased-donor kidney transplantation.

Methods

The study cohort consists of 1025 recipient-donor pairs transplanted in a single center from 2007 to 2017 in Helsinki. The associations between the sums of whole-genome missense variant mismatches and missense mismatches in transmembrane, secretory, and kidney-related proteins, with acute rejection were estimated using Cox model. In addition, we analyzed 40 deletion-tagging variants using Cox model.

Results

The association analysis between mismatch sums of kidney-related proteins and acute rejection resulted in an

SUBMITTER: Markkinen S 

PROVIDER: S-EPMC9751710 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature