Association between lower body temperature and increased tau pathology in cognitively normal older adults.

ABSTRACT:

Background

Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in Alzheimer's Disease (AD). Tau phosphorylation is substantially increased by a small (<1 °C) decrease in temperature within the human physiological range, and thermoregulatory nuclei are affected by tau pathology early in the AD continuum. In this study we evaluated whether Tb (as a proxy for brain temperature) is cross-sectionally associated with clinically utilized markers of tau pathology in cognitively normal older adults.

Methods

Tb was continuously measured with ingestible telemetry sensors for 48 h. This period included two nights of nocturnal polysomnography to delineate whether Tb during waking vs sleep is

SUBMITTER: Blessing EM 

PROVIDER: S-EPMC9751849 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature