Omega 3 supplementation reduces C-reactive protein, prostaglandin E₂ and the granulocyte/lymphocyte ratio in heavy smokers: An open-label randomized crossover trial.

ABSTRACT:

Objectives

Given the current controversy concerning the efficacy of omega 3 supplements at reducing inflammation, we evaluated the safety and efficacy of omega 3 on reducing inflammation in people with a 6-year lung cancer risk >1.5% and a C reactive protein (CRP) level >2 mg/L in a phase IIa cross-over study.

Materials and methods

Forty-nine healthy participants ages 55 to 80, who were still smoking or had smoked in the past with ≥30 pack-years smoking history, living in British Columbia, Canada, were randomized in an open-label trial to receive 2.4 g eicosapentaenoic acid (EPA) + 1.2 g docosahexaenoic acid (DHA)/day for 6 months followed by observation for 6 months or observation for 6 months first and then active treatment for the next 6 months. Blood samples were collect

SUBMITTER: Elisia I 

PROVIDER: S-EPMC9751896 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature