Microenvironmental changes co-occur with mosaic somatic clonal expansions in normal skin and esophagus tissues.

ABSTRACT: The presence of somatic mutations, previously identified in cancers, are being increasingly recognized in normal tissues. While the role of microenvironment (ME) in tumor progression is well understood, the changes that occur in the microenvironment of normal tissues that harbor somatic mutations has not been systematically studied. Here, using normal RNA-Seq data accrued from 6544 samples across 27 tissue types from Genotype-Tissue Expression (GTEx) project, we studied the association of microenvironmental changes in the presence of somatic clonal expansions of previously implicated cancer genes. We focused our analysis on skin and esophagus since they have the highest number of samples and mutation burden together. We observed changes in microenvironmental cell-types previously implicate

SUBMITTER: Munugula C 

PROVIDER: S-EPMC9751946 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature