β-lactam precision dosing in critically ill children: Current state and knowledge gaps.

ABSTRACT: There has been emerging interest in implementing therapeutic drug monitoring and model-informed precision dosing of β-lactam antibiotics in critically ill patients, including children. Despite a position paper endorsed by multiple international societies that support these efforts in critically ill adults, implementation of β-lactam precision dosing has not been widely adopted. In this review, we highlight what is known about β-lactam antibiotic pharmacokinetics and pharmacodynamics in critically ill children. We also define the knowledge gaps that present barriers to acceptance and implementation of precision dosing of β-lactam antibiotics in critically ill children: a lack of consensus on which subpopulations would benefit most from precision dosing and the uncertainty of how precision d

SUBMITTER: Tang Girdwood S 

PROVIDER: S-EPMC9752101 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature