Association of ACE2 gene functional variants with gestational diabetes mellitus risk in a southern Chinese population.

ABSTRACT:

Objective

To explore the relationship between angiotensin-converting enzyme 2 (ACE2) genetic variants and gestational diabetes mellitus (GDM) in a southern Chinese population.

Methods

Potential functional variants (rs2106809, rs6632677, and rs2074192) of ACE2 were selected and genotyped in 566 GDM patients and 710 normal pregnaõncies in Guilin, China. The odds ratio (OR) and its corresponding 95% confidence interval (CI) were used to evaluate the association between genetic variant and GDM risk, and then the false positive report probability, multifactor dimensional reduction (MDR), and bioinformatics tools were used to confirm the significant association in the study.

Results

After adjusting for age and prepregnancy body mass index, logistic regression analysi

SUBMITTER: Huang G 

PROVIDER: S-EPMC9752565 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature