The CARDS toxin of Mycoplasma pneumoniae induces a positive feedback loop of type 1 immune response.

ABSTRACT:

Background

Within the past 3-5 years, Mycoplasma pneumoniae has become a major pathogen of community-acquired pneumonia in children. The pathogenic mechanisms involved in M. pneumoniae infection have not been fully elucidated.

Methods

Previous protein microarray studies have shown a differential expression of CXCL9 after M. pneumoniae infection. Here, we conducted a hospital-based study to explore the clinical significance of the type 1 immune response inflammatory factors interferon (IFN)-γ and CXCL9 in patients with M. pneumoniae pneumonia (MPP). Then, through in vitro experiments, we explored whether CARDS toxin stimulated F-DCs (dendritic cells incubated with Flt3L) to promote Th-cell differentiation; we also investigated the IFN-γ-indu

SUBMITTER: Wang T 

PROVIDER: S-EPMC9752573 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature