Characterisation of parasympathetic ascending nerves in human colon.

ABSTRACT:

Background

In the human large bowel, sacral parasympathetic nerves arise from S2 to S4, project to the pelvic plexus ("hypogastric plexus") and have post-ganglionic axons entering the large bowel near the rectosigmoid junction. They then run long distances orally or aborally within the bowel wall forming "ascending nerves" or "shunt fascicles" running in the plane of the myenteric plexus. They form bundles of nerve fibres that can be distinguished from the myenteric plexus by their straight orientation, tendency not to merge with myenteric ganglia and greater width.

Aim

To identify reliable marker(s) to distinguish these bundles of ascending nerves from other extrinsic and intrinsic nerves in human colon.

Methods

Human colonic segments were obtained with informed cons

SUBMITTER: Johnson ME 

PROVIDER: S-EPMC9752816 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature