Cerebellar correlates of social dysfunction among individuals at clinical high risk for psychosis.

ABSTRACT:

Introduction

Social deficits are a significant feature among both individuals with psychosis and those at clinical high-risk (CHR) for developing psychosis. Critically, the psychosis risk syndrome emerges in adolescence and young adulthood, when social skill development is being fine-tuned. Yet, the underlying pathophysiology of social deficits in individuals at CHR for psychosis remains unclear. Literature suggests the cerebellum plays a critical role in social functioning. Cerebellar dysfunction in psychosis and CHR individuals is well-established, yet limited research has examined links between the cerebellum and social functioning deficits in this critical population.

Method

In the current study, 68 individuals at CHR for developing psychosis and 66 healthy controls (HCs

SUBMITTER: Frosch IR 

PROVIDER: S-EPMC9752902 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature