CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population.

ABSTRACT:

Objectives

Ischemic stroke (IS) is the major cause of death and disability. While previous studies confirmed that CYP11B1 is closely associated with IS, the present study aimed to analyze the impact of CYP11B1 gene polymorphisms on the IS susceptibility.

Methods

The present study genotyped six single nucleotide polymorphisms (SNPs) (including rs4736312, rs5017238, rs5301, rs5283, rs6410, and rs4534) of CYP11B1 in peripheral blood samples from IS and control populations. Logistic regression analysis was used to analyze the association between the SNPs and IS risk. The multifactor dimensionality reduction (MDR) method was used to determine the roles of SNP-SNP interactions in IS.

Results

The present study showed that rs5283 was associated with an in

SUBMITTER: Liu G 

PROVIDER: S-EPMC9752905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature