An electrochemical nitric oxide generator for in-home inhalation therapy in pulmonary artery hypertension.

ABSTRACT:

Background

Inhaled NO is a selective pulmonary vasodilator proven to be therapeutic for patients with pulmonary artery hypertension (PAH). The most common NO delivery system in clinical practice is cylinder-based, but unfortunately limited by its high costs, complicated delivery, and the requirement of an extensive supply chain, leaving vast unmet medical needs globally.

Methods

To address the need for rapid, affordable, and safe production of nitric oxide (NO) for in-home inhalation therapy in patients with PAH. We developed a novel portable device to derive NO from a nitrite complex solution with a copper(II)-ligand catalyst, and further examined its effectiveness in a porcine model of PAH. This model was established by using female Bama miniature pig and induced by monocr

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9753075 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature