Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum.

ABSTRACT: The phenylspirodrimanes (PSDs) from Stachybotrys chartarum represent a structurally diverse group of meroterpenoids, which, on the one hand, exhibit a structural exclusivity since their occurrence is not known for any other species and, on the other hand, offer access to chemically and biologically active compounds. In this study, phenylspirodrimanes 1-3 were isolated from S. chartarum and their water-mediated Cannizzaro-type transformation was investigated using quantum chemical DFT calculations substantiated by LC-MS and NMR experiments. Considering the inhibitory activity of PSDs against proteolytic enzymes and their modulatory effect on plasminogen, PSDs 1-3 were used as a starting material for the synthesis of their corresponding biologically

SUBMITTER: Steinert K 

PROVIDER: S-EPMC9753195 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature