Aedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation.

ABSTRACT:

Background

Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis. We have previously shown that systemic activation of the Toll immune pathway via silencing of the negative regulator Cactus in Aedes aegypti blocks parasite development in the Malpighian tubules (MT), the mosquito renal organ. However, it was not established whether the MT were directly responding to Toll activation or were alternatively responding to upregulated proteins or other changes to the hemolymph driven by other tissues. Distinguishing these possibilities is crucial for developing more precise strategies to block D. immitis while potentially avoiding the fitness cost to the mosquito associated with Cactus silencing.

SUBMITTER: Sneed SD 

PROVIDER: S-EPMC9753289 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature