Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders.

ABSTRACT:

Objective

High intake of caffeoylquinic acid (CQA)-rich dietary supplements, such as green coffee bean extracts, offers health-promoting effects on maintaining metabolic homeostasis. Similar to many active herbal ingredients with high pharmacological activities but low bioavailability, CQA has been reported as a promising thermogenic agent with anti-obesity properties, which contrasts with its poor oral absorption. Intestinal tract is the first site of CQA exposure and gut microbes might react quickly to CQA. Thus, it is of interest to explore the role of gut microbiome and microbial metabolites in the beneficial effects of CQA on obesity-related disorders.

Results

Oral CQA supplementation effectively enhanced energy expenditure by activating browning of adipose and thus ame

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9753294 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature