Clinicopathologic features and abnormal signaling pathways in plasmablastic lymphoma: a multicenter study in China.

ABSTRACT:

Background

Plasmablastic lymphoma (PBL) is a rare but aggressive B-cell lymphoma subtype with poor prognosis. Knowledge about the etiology, clinicopathologic and molecular features, and outcomes of PBL is limited. This study aimed to examine the clinicopathologic characteristics, therapeutic approaches, and clinical outcomes of PBL patients in a Chinese population.

Methods

A total of 102 PBL patients were recruited from three cancer centers. The pathologic features and clinical outcomes of 56 patients with available treatment details and follow-up data were reviewed and analyzed. RNA sequencing was performed in 6 PBL and 11 diffuse large B-cell lymphoma (DLBCL) patients.

Results

Most patients in our cohort were male (n = 36, 64.3%), and 35 patients presented with Ann

SUBMITTER: Shi D 

PROVIDER: S-EPMC9753322 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature