Leishmania infantum infection does not affect the main composition of the intestinal microbiome of the Syrian hamster.

ABSTRACT:

Background

Visceral leishmaniasis (VL) is the most severe form of all leishmanial infections and is caused by infection with protozoa of Leishmania donovani and Leishmania infantum. This parasitic disease occurs in over 80 countries and its geographic distribution is on the rise. Although the interaction between the intestinal microbiome and the immune response has been established in several pathologies, it has not been widely studied in leishmaniasis. The Syrian hamster is the most advanced laboratory model for developing vaccines and new drugs against VL. In the study reported here, we explored the relationship between the intestinal microbiome and infection with L. infantum in this surrogate host.

Methods

Male Syrian hamsters (120-140 g) were inoculated with 10⁸

SUBMITTER: Olias-Molero AI 

PROVIDER: S-EPMC9753363 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature