Comprehensive analysis of the expression, prognostic significance, and regulation pathway of G2E3 in breast cancer.

ABSTRACT:

Background

Loss of G2-specific E3-like (G2E3) protein sensitizes tumor cells to chemotherapy. However, the role of G2E3 in breast cancer development and patient's prognosis is unclear. Here, we explored the expression, prognostic significance, and regulatory pathway of G2E3 in breast cancer.

Methods

TCGA and UALCAN database were utilized to explore G2E3 expression in breast cancer and normal tissues and its expression in breast cancer based on clinicopathological characteristics, respectively. The Kaplan-Meier plotter database was utilized to determine the effect of G2E3 on the prognosis of breast cancer patients. RT-PCR was utilized to validate the G2E3 expression in cancerous and normal breast tissues. Immunohistochemistry analysis was utilized to validate the prognostic e

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9753372 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature