Neutrophil CD64 index for diagnosis of infectious disease in the pediatric ICU: a single-center prospective study.

ABSTRACT:

Background

Infection is a major cause of death in children, and it is particularly important to identify biological indicators of early infection. Previous studies showed that the neutrophil CD64 (nCD64) index may be a useful biomarker for infection. The purpose of this study was to investigate use of the nCD64 index to identify infection in children from a pediatric ICU (PICU) in China.

Methods

This prospective observational study enrolled 201 children who were admitted to our PICU and were divided into an infection group and a non-infection group. In each patient, C-reactive protein (CRP), nCD64 index, procalcitonin (PCT), and white blood cell count were measured during the first 24 h after admission. Receiver operating characteristic (ROC) analyses were used to determine

SUBMITTER: Cao LL 

PROVIDER: S-EPMC9753391 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature