Metabolic engineering of Corynebacterium glutamicum for acetate-based itaconic acid production.

ABSTRACT:

Background

Itaconic acid is a promising platform chemical for a bio-based polymer industry. Today, itaconic acid is biotechnologically produced with Aspergillus terreus at industrial scale from sugars. The production of fuels but also of chemicals from food substrates is a dilemma since future processes should rely on carbon sources which do not compete for food or feed. Therefore, the production of chemicals from alternative substrates such as acetate is desirable to develop novel value chains in the bioeconomy.

Results

In this study, Corynebacterium glutamicum ATCC 13032 was engineered to efficiently produce itaconic acid from the non-food substrate acetate. Therefore, we rewired the central carbon and nitrogen metabolism by inactivating the transcriptional regulator RamB,

SUBMITTER: Schmollack M 

PROVIDER: S-EPMC9753420 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature