Agent-based model of the impact of higher influenza vaccine efficacy on seasonal influenza burden.

ABSTRACT:

Introduction

Current influenza vaccines have limited effectiveness. COVID-19 vaccines using mRNA technology have demonstrated very high efficacy, suggesting that mRNA vaccines could be more effective for influenza. Several such influenza vaccines are in development. FRED, an agent-based modeling platform, was used to estimate the impact of more effective influenza vaccines on seasonal influenza burden.

Methods

Simulations were performed using an agent-based model of influenza that included varying levels of vaccination efficacy (40-95 % effective). In some simulations, level of infectiousness and/or length of infectious period in agents with breakthrough infections was also decreased. Impact of increased and decreased levels of vaccine uptake were also modeled. Outcomes incl

SUBMITTER: Krauland MG 

PROVIDER: S-EPMC9753457 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature