A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection.

ABSTRACT:

Background

Patients who present to an emergency department (ED) with respiratory symptoms are often conservatively triaged in favour of hospitalisation. We sought to determine if an inflammatory biomarker panel that identifies the host response better predicts hospitalisation in order to improve the precision of clinical decision making in the ED.

Methods

From April 2020 to March 2021, plasma samples of 641 patients with symptoms of respiratory illness were collected from EDs in an international multicentre study: Canada (n=310), Italy (n=131) and Brazil (n=200). Patients were followed prospectively for 28 days. Subgroup analysis was conducted on confirmed coronavirus disease 2019 (COVID-19) patients (n=245). An inflammatory profile was determined using a rapid, 50-min, biom

SUBMITTER: Husain S 

PROVIDER: S-EPMC9753477 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature