Food-induced dopamine signaling in AgRP neurons promotes feeding.

ABSTRACT: Obesity comorbidities such as diabetes and cardiovascular disease are pressing public health concerns. Overconsumption of calories leads to weight gain; however, neural mechanisms underlying excessive food consumption are poorly understood. Here, we demonstrate that dopamine receptor D1 (Drd1) expressed in the agouti-related peptide/neuropeptide Y (AgRP/NPY) neurons of the arcuate hypothalamus is required for appropriate responses to a high-fat diet (HFD). Stimulation of Drd1 and AgRP/NPY co-expressing arcuate neurons is sufficient to induce voracious feeding. Delivery of a HFD after food deprivation acutely induces dopamine (DA) release in the ARC, whereas animals that lack Drd1 expression in ARC^AgRP/NPY neurons (Drd1^AgRP-KO) exhibit attenuated foraging and refeeding

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9753708 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature