An autophagy-related four-lncRNA signature helps to predict progression-free survival of neuroblastoma patients.

ABSTRACT:

Background

This study aimed to identify autophagy-related long non-coding RNAs (lncRNAs) associated with progression of neuroblastoma (NB), and to build an autophagy-related lncRNA signature that helps to predict progression-free survival (PFS) of NB.

Methods

Three independent gene expression datasets were utilized in this study. Autophagy-related genes (ARG) associated with PFS of NB patients were firstly identified by univariate Cox survival analysis. lncRNAs correlated with those PFS-related ARGs were then identified. The least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression analyses were performed to select out those lncRNAs with the best prognostic value for PFS. The Receiver Operating Characteristic (ROC) and Area Under Curv

SUBMITTER: Wang J 

PROVIDER: S-EPMC9753905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature