Cellular functions of the ClpP protease impacting bacterial virulence.
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ABSTRACT:
SUBMITTER: Aljghami ME
PROVIDER: S-EPMC9753991 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Cellular functions of the ClpP protease impacting bacterial virulence.
Aljghami Mazen E ME Barghash Marim M MM Majaesic Emily E Bhandari Vaibhav V Houry Walid A WA
Frontiers in molecular biosciences 20221201
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent degradation of target substrates. ClpX is a hexameric unfoldase ATPase, while ClpP is a tetradecameric serine protease. Substrates of ClpXP belong to many cellular pathways such as DNA damage response, metabolism, and transcriptional regulation. Crucia ...[more]
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