Birthweight, genetic risk, and gastrointestinal cancer incidence: a prospective cohort study.

ABSTRACT:

Background

The epidemiologic studies investigating the association of birthweight and genetic factors with gastrointestinal cancer remain scarce. The study aimed to prospectively assess the interactions and joint effects of birthweight and genetic risk levels on gastrointestinal cancer incidence in adulthood.

Methods

A total of 254,997 participants were included in the UK Biobank study. We used multivariate restricted cubic splines and Cox regression models to estimate the hazard ratios (HRs) and 95% confidential intervals (CI) for the association between birthweight and gastrointestinal cancer risk, then constructed a polygenic risk score (PRS) to assess its interaction and joint effect with birthweight on the development of gastrointestinal cancer.

Results

We docume

SUBMITTER: Long L 

PROVIDER: S-EPMC9754019 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature