Potential biomarkers for active renal involvement in systemic lupus erythematosus patients.

ABSTRACT:

Objective

This study aimed to identify the key genes related to active renal involvement in patients with systemic lupus erythematosus (SLE).

Methods

Microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between SLE patients with active renal involvement and those who did not have active renal involvement were identified by R software. Hub genes were identified using protein-protein interaction networks. The relationships between the expression levels of identified hub genes and SLEDAI were subjected to linear correlation analysis. The diagnostic accuracy of the hub genes was evaluated with the area under the curve of the receiver operating characteristic curve (ROC-AUC). Transcription factors (TFs) were pr

SUBMITTER: Xiao L 

PROVIDER: S-EPMC9754094 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature