Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC9754124 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Liu Qiaoming Q Liang Yingjian Y Wang Dong D Li Jie J
Frontiers in genetics 20221201
The identification of cell types in complex tissues is an important step in research into cellular heterogeneity in disease. We present a linear fast semi-supervised clustering (LFSC) algorithm that utilizes reference samples generated from bulk RNA sequencing data to identify cell types from single-cell transcriptomes. An anchor graph is constructed to depict the relationship between reference samples and cells. By applying a connectivity constraint to the learned graph, LFSC enables the preser ...[more]