Using genetic data to identify transmission risk factors: Statistical assessment and application to tuberculosis transmission.

ABSTRACT: Identifying host factors that influence infectious disease transmission is an important step toward developing interventions to reduce disease incidence. Recent advances in methods for reconstructing infectious disease transmission events using pathogen genomic and epidemiological data open the door for investigation of host factors that affect onward transmission. While most transmission reconstruction methods are designed to work with densely sampled outbreaks, these methods are making their way into surveillance studies, where the fraction of sampled cases with sequenced pathogens could be relatively low. Surveillance studies that use transmission event reconstruction then use the reconstructed events as response variables (i.e., infection source status of each sampled case) and use hos

SUBMITTER: Goldstein IH 

PROVIDER: S-EPMC9754595 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature