Stress and reward: A multimodal assessment of childhood sexual abuse.

ABSTRACT:

Background

Childhood adversity has been found to impact stress and brain reward systems but it is unclear whether interactions between these systems might explain resilient vs. non-resilient trajectories following childhood sexual abuse (CSA). To address this gap, we adopted a multimodal approach in which cortisol reactivity to an acute stressor was assessed in conjunction with behavioral and neural measures of reward responsiveness in females with major depressive disorder (MDD) or no psychiatric disorders (i.e., resilient) who experienced CSA compared to females with and without MDD who did not experience abuse.

Methods

Latent Class Mixed Modelling (LCMM) identified classes of adults (n = 62; M_Age = 26.48, SD = 5.68) characterized by distinct cortisol tra

SUBMITTER: Pechtel P 

PROVIDER: S-EPMC9755059 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature