Association between uric acid and height during growth hormone therapy in children with idiopathic short stature

ABSTRACT:

Background

Serum uric acid (UA) within appropriate levels is reported to be beneficial in patients with idiopathic short stature (ISS). This study aimed to evaluate the association between serum UA levels and height standard deviation scores (SDS) in patients with ISS during growth hormone (GH) therapy.

Methods

A longitudinal study (LG Growth Study) of 182 children (mean age: 7.29±2.60 years) with ISS was performed. All participants were in the prepubertal stage and treated with GH, and the data within a treatment period of 30 months were analyzed.

Results

In the adjusted Pearson’s correlation, UA was significantly correlated with height SDS after controlling for sex, age, and body mass index (BMI) SDS (r=0.22, p=0.007). In the adjusted multiple regression analys

SUBMITTER:  

PROVIDER: S-EPMC9755161 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature