Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy.

ABSTRACT: Herein, we employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatments on female mice. Controlling the addition of precursor HAuCl₄ allows for the fabrication of different atomic ratios of Au_xCu_y. X-ray absorption near edge spectra indicates that Au and Cu are the predominant oxidation states of zero valence. This suggests that the charges of Au and Cu remain unchanged after galvanic replacement. Specifically, Au_0.02Cu_0.98 composition reveals the enhanced •OH generation following O₂ → H₂O₂ → •OH. The degradable Au_0.02Cu_0.98 released Cu⁺ and Cu²⁺ resulting in oxygen reduction and Fenton-li

SUBMITTER: Wang LC 

PROVIDER: S-EPMC9755215 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature