Altered functional connectivity during performance feedback processing in multiple sclerosis

ABSTRACT: Highlights • Cognitive fatigue does not impact learning from feedback in multiple sclerosis (MS).• Cortico-striatal regions are activated during feedback processing in MS.• Enhanced connectivity between striatal and task-relevant regions also occurs in MS.• MS may engage alternative striatal connections to aid feedback-based learning. Effective learning from performance feedback is vital for adaptive behavior regulation necessary for successful cognitive performance. Yet, how this learning operates in clinical groups that experience cognitive dysfunction is not well understood. Multiple sclerosis (MS) is an autoimmune, degenerative disease of the central nervous system characterized by physical and cognitive dysfunction. A highly prevalent impairment in MS is cognitive fatigue (CF). CF is

SUBMITTER: Cagna C 

PROVIDER: S-EPMC9755233 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature