Aging and aging-related diseases: from molecular mechanisms to interventions and treatments.

ABSTRACT: Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. Although the development of modern medicine has promoted human health and greatly extended life expectancy, with the aging of society, a variety of chronic diseases have gradually become the most important causes of disability and death in elderly individuals. Current research on aging focuses on elucidating how various endogenous and exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss of proteostasis, compromise of au

SUBMITTER: Guo J 

PROVIDER: S-EPMC9755275 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature