Determining the association between gut microbiota and its metabolites with higher intestinal Immunoglobulin A response.

ABSTRACT: Immunoglobulin A (IgA) is one of the important and most abundant immunoglobulins which neutralize invading pathogens at mucosal sites. Gut microbial community and their metabolites which are responsible for higher IgA are poorly known. The current study was carried out to determine those microbial community and their metabolites. Twenty-two healthy, 26 days wean piglets were used in the study. After 10 days of weaning, piglets were divided into two groups. Group 1 with significantly higher fecal IgA while group 2 with significantly lower IgA concentrations from each other. Both groups were analyzed for the fecal inflammatory cytokine, fecal microbial community using 16S ribosomal sequencing, and microbial metabolites using GC-MS. Results showed that Firmicutes and Bacteroidetes constituted

SUBMITTER: Rajput M 

PROVIDER: S-EPMC9755367 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature