Causal association of sleep disturbances and low back pain: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have shown that low back pain (LBP) often coexists with sleep disturbances, however, the causal relationship remains unclear. In the present study, the causal relationship between sleep disturbances and LBP was investigated and the importance of sleep improvement in the comprehensive management of LBP was emphasized.

Methods

Genetic variants were extracted as instrumental variables (IVs) from the genome-wide association study (GWAS) of insomnia, sleep duration, short sleep duration, long sleep duration, and daytime sleepiness. Information regarding genetic variants in LBP was selected from a GWAS dataset and included 13,178 cases and 164,682 controls. MR-Egger, weighted median, inverse-variance weighted (IVW), penalized weighted medi

SUBMITTER: Luo G 

PROVIDER: S-EPMC9755499 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature