Bidirectional two-sample Mendelian randomization study of causality between rheumatoid arthritis and myocardial infarction.

ABSTRACT:

Background

Epidemiological evidence suggests an association between rheumatoid arthritis (RA) and myocardial infarction (MI). However, causality remains uncertain. Therefore, this study aimed to explore the causal association between RA and MI.

Methods

Using publicly available genome-wide association study summary datasets, bidirectional two-sample Mendelian randomization (TSMR) was performed using inverse-variance weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode methods.

Results

The MR results for the causal effect of RA on MI (IVW, odds ratio [OR] = 1.041, 95% confidence interval [CI]: 1.007-1.076, P = 0.017; weighted median, OR = 1.027, 95% CI: 1.006-1.049, P = 0.012) supported a causal association between genetic s

SUBMITTER: Guo HY 

PROVIDER: S-EPMC9755576 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature