NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation.

ABSTRACT:

Introduction

Studies of NK cells in tumors have primarily focused on their direct actions towards tumor cells. We evaluated the impact of NK cells on expression of homing receptor ligands on tumor vasculature, intratumoral T cell number and function, and T cell activation in tumor draining lymph node.

Methods

Using an implantable mouse model of melanoma, T cell responses and homing receptor ligand expression on the vasculature were evaluated with and without NK cells present during the early stages of the tumor response by flow cytometry.

Results

NK cells in early-stage tumors are one source of IFNγ that augments homing receptor ligand expression. More significantly, NK cell depletion resulted in increased numbers of intratumoral T cells with an anergic phenotype. Ane

SUBMITTER: Lindsay RS 

PROVIDER: S-EPMC9755581 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature