A novel enterocyte-related 4-gene signature for predicting prognosis in colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is a fatal disease, and its cases are constantly increasing worldwide. Further, the therapeutic and management strategies for patients with COAD are still unsatisfactory due to the lack of accurate patient classification and prognostic models. Therefore, our study aims to identify prognostic markers in patients with COAD and construct a cell subtype-specific prognostic model with high accuracy and robustness.

Methods

Single-cell transcriptomic data of six samples were retrieved from the Gene expression omnibus (GEO) database. The cluster annotation and cell-cell communication analysis identified enterocytes as a key player mediating signal communication networks. A four-gene signature prognostic model was constructed based on the entero

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9755665 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature