Leveraging biochemical reactions to unravel functional impacts of cancer somatic variants affecting protein interaction interfaces.

ABSTRACT: Background: Considering protein mutations in their biological context is essential for understanding their functional impact, interpretation of high-dimensional datasets and development of effective targeted therapies in personalized medicine. Methods: We combined the curated knowledge of biochemical reactions from Reactome with the analysis of interaction-mediating 3D interfaces from Mechismo. In addition, we provided a software tool for users to explore and browse the analysis results in a multi-scale perspective starting from pathways and reactions to protein-protein interactions and protein 3D structures. Results: We analyzed somatic mutations from TCGA, revealing several significantly impacted reactions and pathways in specific cancer types. We found examples of g

SUBMITTER: Raimondi F 

PROVIDER: S-EPMC9755755 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature